Role of Osteoprotegerin as Novel Marker in Urinary Stone Formers: A Pilot Study

Background: Urinary tract calculus formation can be prevented by identifying molecules and metabolic disturbances that affect this process. Osteoprotegerin (OPG), a cytokine of the TNF receptor superfamily, has been demonstrated to mediate vascular calcification intimal calcification. Endothelial injury oxidative stress are known play role in urolithiasis form Randall’s plaques. Objectives: The present study aimed compare 24-h urinary serum OPG levels patients with without urolithiasis. Methods: In case-control study, (pg/mL), creatinine (mg/dL) were measured both groups. determined enzyme-linked immunosorbent assay (ELISA) using human kits. Results: Mean was 0.86 ± 0.21 mg/dL case group 0.77± 0.16 controls. difference mean between cases (227.13 98.02 pg/mL) controls (47.28 29.61 highly significant (P value < 0.0001). (156.12 174.31 (9.32 23.72 0.001). Conclusions: There significantly higher urine samples than Hence, it requires further large studies make diagnostic prognostic marker.